Jesse Muskin was Jeff Muskin's wife.
Earl returned the wallet he stole to Jeff, who explained that he had not been able to go on his honeymoon because of Earl. Jesse, who was in a tanning bed, suddenly appeared and angrily told Earl off for stealing the money. Earl offered to fill in for Jeff at his job for a week whilst he and Jesse went on their honeymoon ("O Karma, Where Art Thou?").